sarcomas of the arm or leg. In some centers, radiotherapy is given both pre- and postoperatively. If the tumor cannot be surgically removed, radiotherapy and chemotherapy are used.
In Stage IVB, if the lung is the only site of spread, cure may be possible in up to 30 percent of patients by aggressive treatment of the primary tumor similar to earlier stages and removal of the lung metastases, even if there are several.
If lung metastases are not removed or there are other sites of metastasis , palliation may be provided by radiotherapy to the primary tumor combined with chemotherapy. Various combinations are used, generally containing doxorubicin and dacarbazine , sometimes with other agents as well. Combinations including ifosfamide are also used.
Standard therapy is not curative, so patients should be considered candidates for clinical trials .
